Presumably you'd only lose taxiway signs in default airports - most 3rd. party sceneries have a bgl file for them, which would not of course be affected.
I've looked at AFX a number of times in the past, but actually it seems quite expensive when AFCAD2 does most of what I want for free, and I am happy to use ADE for small tasks. (I almost never use FSX).. I spend so much money on scenery (and to a lesser extent, aircraft) already!!
Yes, it works perfectly.

As per my edit, not on my setup, it almost never does. AI traffic are still using 32R for landing, though it is clearly marked 'closed for landing'..
M.