Basically yes, Randomizer can be used with any aircraft.
You will get the most out of the Randomizer if you fly IFR because the key element of Randomizer is the randomization of the SID/STAR option and the procedure names.
If you fly IFR with our GA aircraft you will be able to fully enjoy Randomizer.
Even if you only fly VFR some features of the Randomizer might stil be useful for you. Have a look at it and decide for yourself.