Last night I was flying into an airport and hit the 1 key to contact the tower. Heard nothing, looked at my comm radio and it was on the wrong frequency. Set the frequency, hit 1 again, and looked, and it had switched to the same wrong frequency again. Tried this one more time, and gave up. Hit the 2 key and announced I was on final and I was cleared to land.
After I landed I checked in the keyboard assignments in MS 2020, and the 1 key is assigned to something like "tune to atis frequency". I disabled this assignment and the problem went away. So it might be a good idea, since there are so many key assignments in MS 2020, to check the common keys you use in PF3, and make sure they aren't assigned to another function.