Options 2 then Advanced options and Ini Tweaks Tab Click on Tab Audio Output Configuration and make sure it's set on "Windows Default" and not Primary Sound Driver or any other devices.
The reason behind this post is recently i must have been tweaking my setup in PF3 and checked/used one of them not thinking will i have any issues as it seemed to work ok...or maybe coinciding with an update put spanner in works because of late and a few e-mails to Dave complaining that PF3 had stopped
I have completed 3 flights this weekend with no issues using the above setup.